Gas6 and protein S
نویسندگان
چکیده
منابع مشابه
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis.
TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. Also, they affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct i...
متن کاملGas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.
Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions. A discrete subset of these functions is mediated through their binding to and activation of the receptor tyrosine kinases Axl, Sky and Mer. Furthermore, a hallmark of the Gas6-Axl system is the unique ability of Gas6 and protein S to tether their non receptor-...
متن کاملGas6 protein: its role in cardiovascular calcification
BACKGROUND Cardiovascular calcifications can be prevented by vitamin K and are accelerated by vitamin K antagonists. These effects are believed to be mainly mediated by the vitamin K-dependent matrix Gla protein. Another vitamin K-dependent protein, Gas6, is also expressed in vascular smooth muscle cells (VSMC). In vitro Gas6 expression was shown to be regulated in VSMC calcification and apopto...
متن کاملReevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3
Recently, Stitt et al. (1995) reported that protein S (PS), but not Gas6, is a potent ligand for the receptor tyrosine kinase known as Rse, Tyro 3, Brt, Sky, and Tif (hereafter referred to as Rse/Tyro 3). PS is an abundant serum protein previously characterized as an essential anticoagu-lant. Gas6, which was identified as a gene whose expression is increased by growth arrest, shares 43% amino a...
متن کاملTAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus
INTRODUCTION The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis. In animal models, absence of TAM kinases is associated with lupus-like disease. To test whether human systemic lupus erythematosus (S...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2006
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2006.05529.x